Fecal Microbiota Transplantation
Fecal microbiota transplantation consists of the transfer of microbiota, isolated from the feces of healthy donors, to individuals with dysbiosis, that is, with an imbalance in their intestinal microbiota. The goal is to treat a specific disease by restoring the balance of bacteria in the intestine.
Process
Eligible donors are chosen because they are healthy and do not pose a risk to beneficiaries. They are carefully selected, after a wide range of blood and fecal analyzes, in order to rule out the presence of various pathogens such as viruses, bacteria and parasites.
The fecal microbiota is isolated from the feces of healthy donors in a controlled environment and in accordance with good manufacturing practices. The microbiota preparations for transplantation can then be administered via enema, colonoscopy, endoscopy or through oral capsules.
This process takes place in a controlled clinical context and with due medical monitoring.
Therapeutic indications
Currently, fecal microbiota transplantation is indicated for the treatment of recurrent infection with Clostridioides Difficile , resistant to antibiotics. The existing bacteria in healthy donors are able to restore the intestinal balance in the transplanted patient and can definitively fight the infection by C. Difficile . The effectiveness of TMF in combating this type of infection reaches 90%.
Infection with C. Difficile . it is one of the most prevalent hospital infections and carries a greater risk of life for users.
The application of TMF in several other pathologies, which affect the gastrointestinal tract, is already being tested in several clinical trials.
More about Clostridioides difficile infection :
Infection with Clostridioides difficile (" Clostridioides difficile infection" -CDI) is one of the main and most serious hospital infections.
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Symptoms of ICD can range from diarrhea to serious, life-threatening complications and is the leading cause of healthcare-associated diarrhea.
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Typically, ICD results from the use of antibiotics that disrupt the normal functioning of intestinal bacteria allowing Clostridioides difficile to proliferate.
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Patients at particular risk of developing ICD are the elderly hospitalized or in long-term care facilities.
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Patients hospitalized with ICDs are up to three times more likely to die in the hospital than those without the infection.
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About 25% of patients with this infection will recur within a month and patients who have had a recurrence have a 40% risk of having a new episode of ICD.
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The biggest problem associated with the treatment of ICDs is the high probability of recurrence of the infection, a fact that causes greater suffering to the patient and substantially increases the costs associated with the health system.
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TMF is an effective solution in the treatment of recurrent ICD, resistant to antibiotics, decreasing the length of hospital stay and the likelihood of recurrence of the infection.